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Generic Revatio

What is Generic Revatio?

Generic Revatio, a first-line treatment for pulmonary arterial hypertension (PAH), contains sildenafil citrate. The chemical acts as a muscle and vascular relaxant, thereby increasing blood inflow. It is used to improve cardiac function and exercise tolerance. Off-label, REVATIO is taken as an erectile dysfunction medication, as it acts in the same way VIAGRA does.

Sildenafil citrate, an active component in REVATIO, is a phosphodiesterase type5 (PDE5) inhibitor. Its action allows cyclic guanosine monophosphate (cGMP) to exert its enzyme activity by improving blood inflow to the penis upon the commensuration of sexual activity.

REVATIO is an USFDA approved drug, which can be dispensed according to a prescription only.

Availability

Generic Revatio comes in tablet form and injectables. White film-coated REVATIO tablets (20 mg) with ‘RVT 20’ and ‘Pfizer’ labels on the sides, are to be taken three times a day, as indicated and prescribed by a physician.

An intravenous form of Generic Revatio, containing 0.8mg/mL sildenafil, is an option for those who cannot tolerate oral medications.

Generic Revatio is manufactured by Pfizer, a pharmaceutical corporation mostly known for VIAGRA.

Indications

Generic Revatio is indicated for use in patients that has been clinically diagnosed with pulmonary arterial hypertension (PAH).

Subsequently, off-label administration of this drug has been implicated for erectile dysfunction. In this case, REVATIO is to be used by males, 18 years and above, suffering from ED.

Commonly prescribed dose is three 20mg tablets per day with or without meal, approximately 6-8 hours apart. Prescription is needed to purchase this drug. Valid prescription can only be issued by a licensed physician.

Precautions

Since REVATIO was designed for pulmonary hypertension, constant monitoring of blood pressure changes must be done. The drug has been associated with hypotension which can be potentially harmful.

Generic Revatio may exacerbate other co-morbidities. Doctors should be made known of patients’ medical and drug history.

It is not to be given to patients that are using cardiac medications such as nitrates. Mixing sildenafil with nitrates, might result in death.

Generic Revatio may increase intraocular pressure that can result in non-arteritic anterior ischemic optic neuropathy (NAION).

Generic Revatio is not to be used in combination with other sildenafil-based compounds and PDE5 inhibitors.

Generic Revatio is contraindicated with HIV drugs, cimetidine, ketoconazole, itraconazole, amlodipine, and macrolide antibiotics.

Special precautions are to be given to patients that have experienced stroke, surgery, angina, hepatic and renal diseases.

Patients should not take REVATIO, if they are in any way allergic to it or to one of its components.

Use of Revatio in conjunction with herbal remedies has not been established. Worsening of the condition or emergence of untoward adverse effects must be immediately reported to the doctor. In these cases, medication must be stopped.

Adverse Reactions

Generic Revatio is generally well-tolerated. In some cases side effects occur.

The following are the list of potential adverse effects:
•Headache
•Flushing
•Dyspepsia
•Fever
•Diarrhea
•Myalgia
•Cough and other flu-like symptoms
•Visual disturbances
•Upper respiratory tract infection
•Nausea
•Asthenia
•Palpitations
•Confusion
•Impaired memory retention
•Hypotension

In the event that these adverse reactions persist, seek medical consultation.

Prolonged use has been associated with Transient Ischemic Attack, pulmonary hemorrhage, subarachnoid and intra-cerebral hemorrhage, and liver and kidney damage.

To ensure safety and high quality of the treatment, REVATIO should be stored at room temperature, away from children, light and moisture.

Overdosage and toxicity should be reported to local health authorities. Call 911 to report medical emergency.

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